Phospho vps34

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August undefined, 2024

WebDescription. This antibody is predicted to react with mouse, porcine and rat based on sequence homology. PI3KC3 is a catalytic subunit of the PI3K complex involved in the transport of lysosomal enzyme precursors to lysosomes. This enzyme acts catalytically to convert 1-phosphatidyl-1D-myo-inositol to 1-phosphatidyl-1D-myo-inositol 3-phosphate. WebPhospho-VPS34 (Ser244, Ser249) Classification. Polyclonal. Conjugate. Unconjugated. Gene. Pik3c3. Gene Alias. 5330434F23Rik; catalytic phosphatidylinositol 3-kinase 3; …

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US20240068698A1 COMBINATION THERAPY FOR CANCER

WebMay 19, 2013 · VPS34 is the only class III phosphoinositide 3-kinase (PI (3)K) in mammals, phosphorylating phosphatidylinositol to produce phosphatidylinositol 3-phosphate (PtdIns (3)P; ref. 13 ). Cellularly,... Webof the VPS34 gene, Vps34p, is associated through protein-protein interactions with an organelle distinct from the vacuole (15, 21). PI 3-kinase activity is readily detected in yeast … Web1.3‑甲基腺嘌呤作为Polo样激酶抑制剂的增敏剂在制备治疗鼻咽癌药物中的应用。 2.根据权利要求1所述应用，其特征是，所述Polo样激酶抑制剂为PLK1抑制剂。 3.根据权利要求2所述应用，其特征是，所述PLK1抑制剂为GW843682X或BI2536。 4.根据权利要求3所述应用，其特征是，所述3‑甲基腺嘌呤在作为PLK1抑制 ... theo sedlmayr attorney

Phospho-VPS34 (Ser164) Polyclonal Antibody, Invitrogen™

Phospho-VPS34 (Ser164) Rabbit anti-Human, Polyclonal, …

WebThree distinct types of phosphoinositide 3-kinases (PI3K) have been characterized. Unlike other PI3Ks, PI3K class III catalyzes the phosphorylation of phosphatidylinositol at the D3 … WebNov 7, 2015 · Vps34, which converts phosphatidylinositol (PtdIns) to PtdIns 3-phosphate (PI(3)P), is the only class III PtdIns 3-kinase (PI3K) in mammals. By forming a stable complex with a putative Ser-Thr protein kinase, Vps15, Vps34 lipid kinase behaves as a key regulator of autophagy initiation and progression (Liang et al., 2006, Matsunaga et al., … theo secure appWebTarget Information VPS34 (PIK3C3) is a catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to … theo seekirchen

"WebDec 9, 2016 · This phosphorylation critically regulates ATG14-Vps34 lipid kinase activity to control autophagy level. We also show that ATG14-associated Vps34 activity and ULK1-mediated phosphorylation of ATG14 and Beclin 1 are compromised in the Q175 mouse model of Huntington’s disease. " - Phospho vps34

Phospho vps34

Anti-PIK3C3 Antibodies Invitrogen - Thermo Fisher Scientific

Web丁香通为您提供CXCR2IN1orb1商品详情介绍：价格：￥2560，货号：orb1183209，CAS号：[1873376-49-8]，详见丁香通CXCR2IN1orb1商品详情页； WebVps34i treatment induced STAT1 and IRF7, involved in the up-regulation of CCL5 and CXCL10. Combining Vps34i improved the therapeutic benefit of anti–PD-L1/PD-1 in …

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WebMar 25, 2024 · Phospho-VPS34 (Ser164) Polyclonal Antibody Catalog # : PA5-12829 Quantity : 400 µL Pricing : US 417 Clonality : Polyclonal Purity : Antigen affinity … WebApr 9, 2024 · Innovate through Integrated Solutions Home; Contact Us; English Deutsch; 日本語; 简体中文; Products. Product Browser; Product Discounts & Benefits

WebNational Center for Biotechnology Information WebGeneral description. Vacuolar protein sorting 34 (VPS34), also known as phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3), is encoded by the gene mapped to human chromosome 18q12.3. The encoded protein belongs to the phosphoinositide (PI)-3-kinase family. [ 1] VPS34 is widely expressed in all tissues of …

WebNov 11, 2024 · The VPS34-p150-beclin-1 complex serves as a binding partner for several proteins, such as Atg14, to promote autophagy. 32, 33 Enhancing the interaction between VPS34 and beclin-1 is capable of promoting autophagy. 34, 35 Our data illustrated that 14-3-3ζ overexpression enhanced the binding of VPS34 and beclin-1 and further triggered … WebTarget Information VPS34 (PIK3C3) is a catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis.

WebFunction. Phosphatidylinositol 3-kinase required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I. This …

WebMar 25, 2024 · Phospho-VPS34 (Ser164) Polyclonal Antibody catalog : PA5-12829 quantity : 400 µL price : US 417 clonality : polyclonal host : domestic rabbit conjugate : nonconjugated antigen modification : phosphorylated reactivity : human application : dot blot more info or order : Invitrogen product webpage image image 1 : product information Product Type : the osees tourWebJan 17, 2013 · Anti-phospho-Beclin1 S91/S94 and Vps34 T163/S165 antibodies were generated by immunizing rabbits with the corresponding phosphopeptides, and the phosphospecific antibodies were affinity purified (Cell Signaling Technology). The details on other antibodies and the reagents can be found in the Extended Experimental Procedures. theo sectionalWebMar 21, 2024 · Phospho-VPS34 (Ser164) Classification: Polyclonal: Gene: PIK3C3: Gene Alias: Phosphatidylinositol 3-kinase catalytic subunit type 3; PtdIns-3-kinase type 3; PI3 … theos eatery orillia tax numberWebPhospho-VPS34 (Ser676) Antibody (PA5-12799) in DB. Dot blot analysis of Phospho-PI3KC3 pSer676 polyclonal antibody ( Product # PA5-12799) on nitrocellulose membrane. … sht webWebDec 10, 2024 · VPS34 immunoprecipitation and VPS34 kinase assay HeLa cells were treated with DMSO (dimethylsulfoxide), MK6-83, or ML-SA1 for 30 min. VPS34 immunoprecipitation was performed in accordance with the ... the osefos videoWeb(1) an inhibitor of macropinocytosis upregulation, wherein the inhibitor of macropinocytosis upregulation is selected from 5-(N-ethyl-N-isopropyl) amiloride (EIPA), 3-methylsulpho theos easton mdWebOct 10, 2014 · The Vps34 (vacuolar protein sorting 34) class III PI3K (phosphoinositide 3-kinase) phosphorylates PtdIns (phosphatidylinositol) at endosomal membranes to generate PtdIns (3) P that regulates membrane trafficking processes via its ability to recruit a subset of proteins possessing PtdIns (3) P -binding PX (phox homology) and FYVE domains. theo segers