WebCD5 expression promotes IL-10 production through activation of the MAPK/Erk pathway and upregulation of TRPC1 channels in B lymphocytes CD5 is constitutively expressed on T cells and a subset of mature normal and leukemic B cells in patients with chronic lymphocytic leukemia (CLL). WebCD5 is a type I transmembrane glycoprotein that is expressed on the surface of T cells and a subset of B cells. Additionally, it is now accepted as a marker of a subset of DC2s (CD1c + DCs) in humans ( 18, 19, 21 ). Although CD5 was initially detected on murine DCs in the early 1990s ( 15, 22 – 24 ), its physiological role is not fully understood.
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